If some Church of Human Cultural Protection had declared Newton’s Laws as final, Einstein never could have proposed General Relativity. If the nature of subatomic particles had been declared “unknowable”, we never would have had quantum physics.
The problem, in our current era, is that we have advanced to a point where many supposed scientists, and particularly their “lay” polemicists, want to declare certain areas more or less done. They do this because there is a fundamental human urge or tendency to want “reality” to be fixed.
Now, in my view, it is quite likely that we will never as individuals EVER have a grasp of “reality”, whatever it is, in this lifetime, and possibly ever. If one is going to take the method of science and deploy it culturally, it has to be done so with humility, and an ACCEPTANCE of the fact that there is much about this universe we may never know, but that many, many things are repeatable and measurable.
Oi: I am physically tired from some hard physical work. I wanted to write this, to get some very rough ideas down, but seem to be faltering. There may yet be something useful here for someone.
Actually, I will add this last thought: I don’t like the word truth. The word I like is useful. Ideas are not true or untrue; they are useful or useless, with both bookending a continuum in between.